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a complete of 12 novel compounds with strong tautomerase activity against MIF ended up uncovered, 4 of which had extraordinary anti-inflammatory efficacy in BV-two microglial cells. These compounds could also markedly suppress the LPS-induced expression of professional-inflammatory cytokines, when their anti-neuroinflammatory effects were abolished when MIF was knocked down by siRNA. What's more, one of the most powerful compound, compound eleven, could inhibit the neurotoxicity of LPS-activated conditioned medium in direction of HT-22 neuroblastoma cells by cutting down inflammatory cytokines and ROS.
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